"It's a bittersweet time," said junior Sarah Bender. "I was in study hall and I was like, these are my last five minutes of high school. And I was just thinking, I'm never going to have this again."
Regina is being forced to close because of economic conditions, and a declining enrollment in Catholic schools in the eastern region of the diocese.
It would have taken an additional $1 million per year to keep the school open.
The hope is that, when the Class of 2010 graduates tonight, the spirit of the school, founded in 1953, will live on.
"All of our alum, and the parent community, they have the Regina spirit," assistant principal Sr. Sally Huston, SND, told WKYC.
"And our motto is learn, serve, and lead. And I think they are taking that with them."
As a remembrance of their school, each of the 40 graduating seniors will receive that motto engraved on a specially designed medallion, which also contains an image of the Virgin Mary.
The senior class is being given credit for keeping the entire student body focused all year, despite the impending closing of the school.
"They made every event a happy event, amidst the tears," Sr. Huston says. "But still let's make it the best, let's make it the greatest, and let's make it the most fun."
While freshmen and sophomores will have to attend completely new schools in the fall, many of the current juniors will have the opportunity to stay together.
Notre Dame College, located right next to Regina, has designed a special program in which girls who are now juniors can complete their high school studies on the Notre Dame campus next year, and actually earn a 2011 Regina diploma.
Thirty of the 40 juniors have opted to take advantage of that unique program, in which they can also earn college credits. Junior Sarah Bender is one of them.
"I intend to not only earn my Regina diploma next year," she said, "but I plan to earn 38 college credits during my senior year in high school."
Girls who opted for the Notre Dame College option will not be eligible for traditional extracurriculars and sports programs, but Bender thought it was worth the sacrifice to stay together as a class and ease the transition.
"My parents said this is what we're doing, and I had no problem with that," she said.
Fellow junior class member Julie Nagy said the goal of carrying on Regina's legacy when the doors close forever on Friday is something they will take part in with pride and enthusiasm.
"My mom also went to Regina," Nagy explained, "and the whole experience of coming to Regina is so unique in its own way. I would never, ever, ever change it in a million years."